Cold Chain Guidance Tool

A greenfield project gives you the ability to plan from scratch for a future cold chain infrastructure process. This is typically characterized by:

• Not a lot of capital invested in infrastructure or freezing workflow tools yet, but possible significant future investment spanning a year or more
• Product will initially flow between one manufacturing site and one filling site, and be expanded over time
• Looking for a complete out-of-the-box, ready-made solution that delivers high throughput at low ongoing operating costs
• Speed to scale and speed to implement are important
• There may be a lot of moving parts and partnering with Entegris will help ensure F/T implementation matches program timelines

With many novel new drugs in development, existing plant and hardware infrastructure may not always be an obvious match for your therapy’s F/T requirements. This may be your challenge if you have:

• Large investment in freezer farms
• Product being produced and processed at multiple sites
• New technologies must be reliable and tested to be considered for use with your high-value product
• Preference to implement completely enclosed processes
• Need solutions to interface optimally with existing installed infrastructure
• Goals to improve throughput and operating costs

As drug manufacturing scales up, there is a primary push to examine processes to reduce operating costs and increase throughput and efficiency. The F/T element of the production process has been identified as a significant bottleneck to production capacity.

• The highest priority is the reduction of total number of primary containers being frozen and shipped
• Primary container volume needs to increase
• To meet throughput requirements, effective freezer space utilization needs to increase

Entegris’ F/T solutions can contribute to your sustainability commitments by:

• Increasing facility space utilization
• Reducing energy use and operating costs
• Eliminating waste and increasing recycling and reuse

There are many areas to optimize typical F/T processes by leveraging best-in-class technology. Entegris can help identify areas to decrease operating costs, increase throughput, and future proof your cold chain infrastructure.